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Fat solubility: Anabolic steroids by nature are lipids (fats), though they are not the traditional chemical characteristic of a hydrocarbon chain. However, if administered in solution, anabolic steroids are known to form hydrocarbons. As such anabolism can occur in a drug that should be metabolized by the liver. A drug will not be “as good” as other drugs at reducing triglyceride levels. The body is capable of metabolizing a drug in its entirety, but does not necessarily have to consume and retain it at the same rate that the liver is metabolizing the drug. Some drugs also have significant amounts of anabolic hormones, which is known as their “anabolic effect” or “anabolic potential.”
The concentration of anabolism in steroids is important to consider when interpreting anabolic steroid abuse reports. While anabolic steroids have been shown to be lipophilic, they will also act with other substances to facilitate more complete conversion of compounds with anabolic effects as well as those with their anti-catabolic effects, allowing users to utilize more than one form of an anabolic steroid. For example, anabolic steroid use can lead to a greater increase in both testosterone (by increasing lipolysis, and by increasing the “anabolic effect”) and the bioavailability of testosterone (by reducing the binding capacity of a steroid (leading to a greater drug concentration)) in the bloodstream. As such, drug abusers will utilize one form of drug at low enough doses to maximize their drug concentration and achieve their desired end, but may ultimately increase other metabolites as well. The higher the concentrations of anabolic steroid metabolites, the more likely one’s drugs will be metabolized by the liver in greater quantity (and consequently the fewer metabolites will be metabolized). Thus the risk of anabolic steroids conversion to other steroid active drugs, including anabolic and anti-catabolic steroid metabolites, is also dependent on the amount of these additional active drugs present in anabolic steroids as well as other metabolites.
Another important issue to consider when studying anabolic steroid intake is the rate at which metabolites will be metabolized, particularly as abuse of anabolic steroids increases. For example, many users of anabolic steroids report the first abuse of anabolic steroid abuse occurs when they become aware that the individual has a significant amount of anabolic steroid present. If the individual does not immediately stop this drug abuse, it is possible for this drug to persist in the body for a long period of time and be converted to other active drugs. Once this happens, abusers may not notice these other drugs, or they may not even realize their use when it persists. Similarly, there may be multiple
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