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Dosages of less than 5 mg prednisolone per day are not significant and no steroid cover is requiredbefore initiation of treatment
Admission to a healthcare provider may require a pre-approval and consent form from a parent
Pregnancy: Post-natal depression may also be treated with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs).
Pre-existing condition: Adverse event reports from post-natal depression patients treated with antidepressants in the general population were similar to those observed in patients treated with buprenorphine.
Pediatric Use
Patients aged less than 6 years were given buprenorphine (100 to 150 mg/day) as a single-dose injection in the primary care setting when medically supervised and followed by an injection of 3 mg of naloxone (Narcan) at 2 to 4 hours. The pediatric literature does not support the recommendation to give doses smaller than 5 mg/day.
Adverse Events
Allergic Reactions
Buprenorphine may trigger anaphylaxis in some patients. See ADVERSE REACTIONS.
Interactions
With alcohol, benzodiazepine, or any other depressant depressant: buprenorphine may cause sedation.
With opiate/opioid medications including: alprazolam, midazolam, methadone, oxycodone, and fentanyl: buprenorphine may worsen respiratory depression, and use of buprenorphine in combination with these medications may cause sedation.
With anticoagulants: buprenorphine may impair renal function.
Hepatic Impairment
Buprenorphine causes severe and reversible liver damage in overdose in an overdose to a mixture of fentanyl and morphine.
General Management
General health care providers should always inform patients of the drug and its potential adverse risks.
General information about buprenorphine
Buprenorphine is a Schedule II controlled substance.
It may cause serious liver damage if it is used in combination with other drugs. There has been a number of cases in which buprenorphine combined with opioids (such as heroin) and alcohol, for example, led to fatal overdoses.
The following is not a complete list of all possible interactions between the drug and its active ingredients. For more information, see:
Abbreviations: ADCA (Adrenocorticotropic Hypotension) ADH (Adrenocortic
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