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1 equipoise and the ethics of clinical research l when is it ethical to initiate a randomized- controlled trial? freedman, nejm, 1987. L “there exists (or in the case. To research the lay public’s understanding of equipoise and randomisation in randomised controlled trials (rcts) and to look at why information on this may not. Equipoise definition in research. Equipoise and the ethics of clinical research. New england journal of medicine. Acknowledgment of uncertainty: a fundamental means to ensure scientific and ethical validity in clinical research. Design: problems related to equipoise can arise in lung cancer studies. Equipoise is an ethics precondition for rcts and exists where there is insufficient. In this article, i aim to bring awareness to two potential ethical challenges sotl researchers might face when playing a dual role of teacher and researcher that are. However, randomization also pre- sents an ethical dilemma for both physician- researchers and research ethics committees. The physician’s ethical and legal duty. Equipoise has long been regarded as a fundamental norm of research ethics, governing the design and conduct of randomized clinical trials (rcts). The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention,. Keywords: trials; ethics; equipoise; uncertainty; therapeutics. O ensaio clínico controlado é considerado o melhor desenho para. The ethics of clinical research requires equipoise — a state of genuine uncertainty on the part of the clinical investigator regarding the
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