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GH is released from the somatotroph cells of the anterior pituitary, with a frequency and amplitude that changes during the day. Its peak secretion occurs after sleep commences, and is age and sex dependent, with maximal secretion occurring around puberty, and its pulsatile release is further modulated by sleep patterns, diet, exercise and stress. As GH is not fat soluble; it exerts its effects via secondary messengers, fat burner sea herbs. The main end-point of GH activity is the liver, where GH leads to the synthesis of insulin- like growth factor 1 (IGF-1), which is consequently the major method of action of GH.
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